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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HLTF
All Species:
22.73
Human Site:
S648
Identified Species:
38.46
UniProt:
Q14527
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14527
NP_003062.2
1009
113929
S648
T
L
R
R
T
K
T
S
K
I
K
G
K
P
V
Chimpanzee
Pan troglodytes
XP_001138277
1009
113822
S648
T
L
R
R
T
K
T
S
K
I
K
G
K
P
V
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_534300
1106
124184
S745
T
L
R
R
T
K
T
S
K
I
K
G
K
P
V
Cat
Felis silvestris
Mouse
Mus musculus
Q6PCN7
1003
113298
S642
T
L
R
R
T
K
T
S
K
I
K
G
K
P
V
Rat
Rattus norvegicus
NP_001099948
974
110023
S613
T
L
R
R
T
K
T
S
K
I
K
G
K
P
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508504
884
99044
P595
L
R
Q
L
C
C
H
P
H
L
F
T
N
T
S
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001090145
999
112576
S638
T
L
R
R
T
K
T
S
K
I
R
G
R
P
V
Zebra Danio
Brachydanio rerio
XP_693071
942
104740
V621
E
R
E
K
Y
E
R
V
K
G
E
G
K
N
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P34739
1061
118357
D694
T
K
A
Q
L
Q
S
D
G
K
L
N
S
L
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786706
1093
121576
Q726
A
L
R
R
M
K
S
Q
K
V
N
G
K
P
L
Poplar Tree
Populus trichocarpa
XP_002308876
799
88908
I510
I
I
L
R
L
R
Q
I
C
N
D
L
A
L
C
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FF61
881
98598
D592
L
R
L
R
Q
L
C
D
D
M
S
L
C
P
P
Baker's Yeast
Sacchar. cerevisiae
P31244
790
91412
A501
G
V
V
L
N
N
Y
A
N
I
F
T
L
I
T
Red Bread Mold
Neurospora crassa
Q7S1P9
1222
137173
M821
V
M
R
R
T
K
D
M
K
T
P
D
G
Q
F
Conservation
Percent
Protein Identity:
100
99.5
N.A.
85.5
N.A.
83.6
81.4
N.A.
71.7
N.A.
64.3
53.1
N.A.
21.1
N.A.
N.A.
34.5
Protein Similarity:
100
99.8
N.A.
88
N.A.
89.7
87.9
N.A.
78.5
N.A.
79.3
69.8
N.A.
41.2
N.A.
N.A.
53.1
P-Site Identity:
100
100
N.A.
100
N.A.
100
100
N.A.
0
N.A.
86.6
20
N.A.
6.6
N.A.
N.A.
53.3
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
13.3
N.A.
100
46.6
N.A.
26.6
N.A.
N.A.
73.3
Percent
Protein Identity:
33.6
N.A.
N.A.
36
22.7
25.2
Protein Similarity:
50.4
N.A.
N.A.
52.7
40.9
43.9
P-Site Identity:
6.6
N.A.
N.A.
13.3
6.6
33.3
P-Site Similarity:
20
N.A.
N.A.
20
20
40
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
0
0
0
0
8
0
0
0
0
8
0
0
% A
% Cys:
0
0
0
0
8
8
8
0
8
0
0
0
8
0
8
% C
% Asp:
0
0
0
0
0
0
8
15
8
0
8
8
0
0
0
% D
% Glu:
8
0
8
0
0
8
0
0
0
0
8
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
15
0
0
0
8
% F
% Gly:
8
0
0
0
0
0
0
0
8
8
0
58
8
0
0
% G
% His:
0
0
0
0
0
0
8
0
8
0
0
0
0
0
0
% H
% Ile:
8
8
0
0
0
0
0
8
0
50
0
0
0
8
8
% I
% Lys:
0
8
0
8
0
58
0
0
65
8
36
0
50
0
0
% K
% Leu:
15
50
15
15
15
8
0
0
0
8
8
15
8
15
8
% L
% Met:
0
8
0
0
8
0
0
8
0
8
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
8
0
0
8
8
8
8
8
8
0
% N
% Pro:
0
0
0
0
0
0
0
8
0
0
8
0
0
58
15
% P
% Gln:
0
0
8
8
8
8
8
8
0
0
0
0
0
8
0
% Q
% Arg:
0
22
58
72
0
8
8
0
0
0
8
0
8
0
0
% R
% Ser:
0
0
0
0
0
0
15
43
0
0
8
0
8
0
8
% S
% Thr:
50
0
0
0
50
0
43
0
0
8
0
15
0
8
8
% T
% Val:
8
8
8
0
0
0
0
8
0
8
0
0
0
0
43
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
8
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _